Some games have an anti-cheat system that prevents the use of LiquidSky's virtual mouse. The technology we use to send the mouse movement from your device to our client is incorrectly categorized by games as a software used to auto-aim or cheat in the game.
If your mouse stops working right after you launch a specific game this is probably why. We advise you to send a message to the developers/support of that game and inform them about this issue. Hopefully they will be able to fix it and detect the mouse on LiquidSky correctly.